Co-Diagnostics, Inc. Announces Advancement of Co-Primers™ Technology in Multiplex SNP Genotyping
Proof of concept study successful in demonstrating potential SNP multiplexing applications
SNP detection refers to finding small-scale but clinically-significant mutations in a given gene using real-time polymerase chain reaction (PCR) testing. Medical applications of SNP detection include identifying the presence of cancer cells or cell-free genetic material in a liquid or tissue biopsy, and to determine the distinct type of cancer involved. A real-life example of this includes being able to identify specific mutation(s) in genes linked to breast cancer in order to determine a patient’s prognosis, initiate the most effective and affordable treatment and to determine whether chemotherapy is necessary. SNP detection is also used in the agricultural industry to identify variations in crop genomes associated with desired characteristics such as higher yield, drought and disease resistance and improved seed viability.
Multiplexing is the ability to identify several different DNA sequences (or loci) simultaneously in a single PCR test procedure, as opposed to conducting several individual procedures. As multiple SNP targets are added to a multiplexed reaction, the individual primer pair molecules used in standard PCR reactions must be designed, optimized and verified independently to ensure they do not cross-react and affect the outcome (i.e. generate a false positive result). The recently completed study confirms the ability of CoPrimers to be used in multiplexed SNP reactions without subsequent re-optimization, allowing researchers or technicians to utilize any combination of primer sets without concerns of cross-reactivity.
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Andrew Benson, 801-438-1036
Lytham Partners, LLC
Joe Diaz, Robert Blum and Joe Dorame